CFHR1 Antibody from MyBioSource.com

Supplier Page

Supplier Page from
MyBioSource.com for
CFHR1 Antibody

Get Pricing
MyBioSource.com's CFHR1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot. The CFHR1 Antibody was generated using CFHR1 as the antigen and it reacts with Human, Mouse, and Rat.

Description

Description: This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
Function: Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
Subunit Structure: Head-to-tail homodimer and heterodimer with CFHR2 or CFHR5.
Post-translational Modifications: N-glycosylated. Two forms are observed; one with a single side chain and the other with two